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產(chǎn)品名稱(chēng): DFFA antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
DFFA antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。DFFA antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
DFFA antibody
的詳細(xì)介紹
DFFA antibodyProduct Profile
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Product Name
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Rabbit anti-DFFA polyclonal antibody - N-terminal region
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Antibody Type
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Primary Antibodies
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Immunogen
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The immunogen for anti-DFFA antibody: synthetic peptide directed towards the N terminal of human DFFA
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DFFA antibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Species Reactivity
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BovineDogGuinea PigHumanMouseRat
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Concentration
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1mg/ml
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Purification
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Protein A
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DFFA antibodyTarget Information
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Gene Symbol
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DFFA
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Gene Synonyms
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DFF-45
DFF1
Ion ChannelAD
ICAD
More
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Gene Full Name
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DNA fragmentation factor, 45kDa, alpha polypeptide
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Gene Summary
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Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
More
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Alternative Names
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DFF-45
DFF1
Ion ChannelAD
ICAD
More
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Molecular Weight(MW)
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37kDa
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Sequence
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331 amino acids
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DFFA antibodyDatabase Links
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Entrez Gene
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1676
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SwissProt ID
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O00273
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Protein Accession
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NP_004392
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DFFA antibodyApplication
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Western blot
5.0ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate
Additional Information
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Form
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Liquid
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Storage Instructions
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Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
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Storage Buffer
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phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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